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Curiously, in 1984 it was recognized that the actual reasons for the electron density missing from a protein structure can be very different (Garner et al., 1998)), i.e., the wholesale movement of a structured domain facilitated by a flexible hinge

Atrophic gastritis , often associated with Helicobacter pylori infection or autoimmunity, reduces gastric acid secretion necessary for releasing food-bound B12

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To study this aspect, we measured the activity of the isolated Ab DGC domain upon mixing with an equal molar ratio of either of the two photocobilin proteins, isolated AdoCbl-bound forms of Ab Pcob or Sas Pcob (with and without bound BV) (Fig