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This is because, in comparison to GLP-1, semaglutide has two amino acid substitutions, which makes it less vulnerable to degradation by the proteolytic enzyme dipeptidyl peptidase-4 (DPP-4) [97] and gives it the distinct advantage of increased albumin affinity [96]
Add summer heat, sweating, travel, cookouts, and outdoor activities into the mix, and hydration becomes even more important
