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If BMI exceeds 30, metabolic syndrome is present, diabetes exists, or previous lifestyle attempts have plateaued despite good adherence, discuss with your provider whether medical evaluation and support options might complement your efforts

Personal or family history of medullary thyroid carcinoma is described as an absolute contraindication, tied to a boxed warning for thyroid C-cell effects seen in animal studies

10.1093/bib/bbv108 101 Milan PicardM