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(19) Thus, changes in the thyroid gland may start long before the symptoms of hormonal imbalances finally manifest

The tumor growth inhibition properties of Ru(II)-OH, NP2, or NP4 (2 mg Ru/kg) were studied upon intravenous injection in the tail vein of 143B tumor bearing mouse models

However, it increased in a dose-dependent manner in MSG-metformin rats, as shown in Figure 3B