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Hi, I was originally diagnosed in 2014 with pernicious Anaemia and after loading doses went on 12 weekly injections, there wasn't much improvement and the nurses treating me managed to geaduly get me down to 8 weeks to where I started to feel an improvement in my symptoms

ScienceDirect

Accumulation of mtDNA damage could impair the OXPHOS system, leading to defects in electron transport chain (ETC) activity, increased ROS generation, and progressive bioenergetic failure, which contribute to the pathogenesis and progression of NDDs [10]

They naturally fluctuate throughout a 24-hour cycle, often dipping when we are most exposed to environmental stressors or when our internal repair mechanisms are working overtime