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The applicant stated that CMS should consider the VersaVue TM Single-Use Flexible Cystoscope application using the same standard applied to other recent decisions for disposable devices and determine that the improved patient outcomes and reduced patient risk associated with the disposable nominated device in comparison with reusable devices is a substantial clinical improvement

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Discussion The findings of this systematic review support the assertion that children with autism spectrum disorders are more likely to have significantly lower tGSH and GSH and significantly increased GSSG, resulting in a significantly lower GSH:GSSG than children without autism