This occurs upon the additional pressure increase of the already severe superior sagittal sinus, portal and caval hypertension (venous hypertension additionally originated within cranium (superior sagittal sinus venography))
It is that a single session or an isolated topical does not address the combination of factors driving melanin overproduction in the first place, which for most people in Miami includes year round ultraviolet exposure and, very often, a skin tone that needs a specific approach
Baradaran B, Safarzadeh E, Safaei S, Baradaran A, Mohammadi A, HajiAsgarzadeh K, Derakhshani A, Argentiero A, Silvestris N, Baradaran B (2020) An emerging approach for combination therapy of cancer: the role of immunogenic cell death, Zhang J-J, Du J, Kong N, Zhang G-Y, Liu M-Z, Liu C
This is similar to what researchers observe with semaglutide getting warm and with tirzepatide left out of the fridge