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The BRAF inhibitor vemurafenib activates mitochondrial metabolism and inhibits hyperpolarized pyruvate-lactate exchange in BRAF-mutant human melanoma cells

As this E3 has now been harnessed to degrade several targets, elucidation of the structural basis of complex formation is essential for optimizing existing FBXO22-recruiting degraders and for enabling the rational design of degraders for additional protein targets

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Most peptides studied show similar safety profiles in men and women