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The BBB consists of endothelial cells tightly joined by tight junctions, supported by astrocytic end-feet and pericytes, which collectively regulate the movement of ions, nutrients, and metabolic waste across the barrier while preventing the entry of pathogens, toxins, and potentially harmful immune cells (Abbott et al., 2010)

The fundamental distinction in subcutaneous vs intramuscular peptide injection lies in the tissue depth reached and the vascular density of that tissue

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& Shahbazi, M.-A