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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

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Mol Breed 11:277285 Medina I, Chudotvorova I (2006) GABA neurotransmission and neural cation-chloride co-transporters: actions beyond ion transport