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The administration of GLP-1RA exendin-4 restored microglial homeostasis, reduced cytokine secretion, and limited astrocyte activation, especially of the A1 phenotype, as well as reduced neuronal apoptosis

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It works by: Slowing gastric emptying , which prolongs feelings of fullness after eating Acting on appetite centres in the brain to reduce hunger signals Improving insulin secretion in response to meals (glucose-dependent mechanism) Reducing glucagon secretion , which helps lower blood glucose levels The weight loss effect of semaglutide typically develops gradually over several months, with patients experiencing reduced appetite and smaller portion sizes