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While some patients may experience temporary changes in reflux symptoms during the initial phases of treatment and weight loss, sustained weight loss typically improves reflux symptoms in the longer term

This enables weekly dosing , the same regimen as Semaglutide, parallel clinical convenience

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Moreover, GLP-1RAs inhibit NADPH oxidase (NOX4)-dependent ROS production and downregulate NLRP3 inflammasome activation, both critical mediators of endothelial injury in diabetes (49)