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This is consistent with the methyl folate trap hypothesis (54), which predicts that, in vitamin B-12 deficiency, the inhibition of DNA synthesis and cell proliferation is removed upon administration of high doses of folic acid because of increased availability of nonmethylated folate

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LC is not restricted to hospitalized patients and its estimated incidence is reported to lie between 10% and 60%, which depends on the definition of LC used and patient cohorts under study (9)