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Only acetaldehyde is capable of forming a covalent interaction with C621 through an aldehyde type of covalent bond (Fig

While pharmacotherapy may delay surgery, it does not replace its role in adolescents with severe obesity and comorbidities

Clinical trials have demonstrated that patients taking Wegovy typically experience around 15% reduction in body weight on average at 68 weeks in trials (with variation among individuals) , largely attributed to decreased calorie intake resulting from these appetite-suppressing effects, as shown in the STEP 1 trial

Use during pregnancy requires caution owing to insufficient safety data