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One study on semaglutide reported an average 6-months weight loss of approximately 11.5 kg (roughly 10%15% of baseline weight) and observed a high proportion of improvement in menstrual cycles ( In clinical practice, weight losses of 5% and 10% are commonly used thresholds for clinical significance. PCOS guidelines state that a weight reduction of 5% can significantly improve insulin sensitivity and hyperandrogenic load, while 10% weight loss is strongly linked to restored ovulation and improved pregnancy rates (78)

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