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Semaglutide reduced the risk of primary outcome by 26% vs placebo, nonfatal stroke by 39%, and nonfatal myocardial infarction by 26%

Secondary endpoints: GSH concentrations in maternal and arterial and venous umbilical cord blood erythrocytes (by stratification based on treatment or degree of IPTB severity) and safety of antenatal NAC supplementation for mothers and infants Considering stratification for IPTB severity, median glutathione concentration in venous cord blood was similar in severe (median: 430 mol/L) and moderate (median: 402 mol/L) IPTB in the NAC arm ( P 1.0), whereas it was lower, however not significantly ( P 0.67), in severe (median: 391 mol/L) than moderate (median: 522 mol/L) IPTB group in the placebo arm (Supplemental Table S3)

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In 2026, the clinical landscape has changed