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UHC may require patients to fail trials of lower-cost medications (like phentermine or topiramate) before approving semaglutide

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Weight regain is possible without enough lifestyle support, such as a healthy diet and exercise

Gut peptide hormones such as GLP-1 could potentially also have an impact on appetite regulation by effects on gastric emptying and direct CNS effects, but we needed a robust methodology that could be used to measure acute effect of putative hormones on subjective appetite and spontaneous food intake