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In addition, evidence suggests that GLP-1 acting outside of the pancreas is also important for regulation of glucose metabolism

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Discussion In the present study, we are the first to demonstrate in an entire national cohort of 424,152 persons with T2D that the use of once-weekly semaglutide independently predicted a 219 fold increased hazard to develop NAION, an untreatable disease most frequently causing severe and irreversible visual loss in the affected eye

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