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27 The other RCT found no significant mean differences between B12 and placebo

While no universal standard exists for assigning edge weights in comorbidity networks, our approach follows established principles in network medicine, where higher weights correspond to greater biological importance and mechanistic connectivity between diseases 31,32

Gut barrier dysfunction can also lead to the transition of microbial metabolites and endotoxins to the blood stream, where these trigger inflammatory cascades and thus contribute to HFpEF

Restoring this tolerance is the holy grail of autoimmune treatment, and selank ability to calm overactive immune signaling while promoting T-cell function may contribute to this goal