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MPH can lead to induced oxidative stress [49,50] by increasing reactive nitrogen and oxygen species that can alter antioxidant defense mechanisms, potentially involving enzymes, which consequently links to lipid, protein, and DNA damage [50,51,52] MPH can cause oxidative damage in the prefrontal cortex by promoting the auto-oxidation of catecholamines, such as dopamine and norepinephrine

Lutrepulse/Lutrelef), but those branded products are largely discontinued and it is now mainly a compounded preparation

Non-heme iron absorption can be inhibited by several dietary factors as well as intraluminal factors (such as excessive alkalinization of the GI tract, malabsorption syndromes, rapid transit time, and absence of digestive juices)

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