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Co-delivery techniques can modulate the signaling pathways that facilitate tumor survival (e.g., PI3K/AKT and NF-B) by sensitizing tumor cells to chemotherapy, overcoming multidrug resistance (MDR) by blocking efflux pumps and disrupting redox homeostasis, or enabling the spatiotemporal delivery of therapeutic agents (e.g., administering a chemotherapy-sensitizing agent followed by a cytotoxic drug) 81,82

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Residence time = 1/ k off