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Reducing nerve pain (neuropathy) caused by diabetes

Patients taking both should discuss monitoring methotrexate levels more frequently, especially during tirzepatide dose escalation

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Mechanisms Beyond Adiposity: The substantial MACE reduction not explained by weight or waist changes points to direct cardiovascular effects, including: Improved endothelial function and vascular health Anti-inflammatory pathways via central GLP-1 receptor signalling Favourable effects on blood pressure and lipid metabolism Possible early adipose tissue metabolic improvements before measurable mass reduction 3