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Challenges: Regulatory complexities across regions, peptide stability and bioavailability, and the need for rigorous quality control

Of the 50 children with T1D, 25 had both detectable I-r-Abs and HLA genetic susceptibility to T1D, 17 had detectable I-r-Abs, but were not typed for HLA, 2 had HLA genetic susceptibility to T1D, but did not have detectable I-r-Abs, 2 had detectable I-r-Abs, but did not have HLA genetic susceptibility to T1D and 4 were neither tested for I-r-Abs nor HLA typed (Table 1)

POI: premature ovarian insufficiency