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Inhibitors of di-peptidyl peptidase-4 (DPP-4), a ubiquitous peptidase that rapidly inactivates GLP-1, also lower fasting glucose in the absence of changes in circulating GLP-1 (8, 9)

J Interferon Cytokine Res 2011;31(9):653-659

It demonstrates that the GLP-1 receptor's activation pathway is "convergent" rather than "pathway-specific": multiple distinct binding events at the extracellular surface can trigger the same conformational rearrangement at the intracellular surface

Theoretically, reducing that chronic inflammation should slow biological aging, he says