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Mutations can also occur in the principal Nrf2 repressor, Keap1 or component of the E3 ubiquitin-ligase complex Cullin 3 (CUL3), with loss of function that renders these factors unable to bind Nrf2 and thus result in persistent Nrf2 activation [68]

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Most SGLT2 inhibitors and GLP-1 agonists are still under patent, but biosimilars and generics are starting to appear in some markets: your pharmacist can advise on the cheapest equivalent option for your prescription

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