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People with Established or with Multiple Risk Factors for Atherosclerotic CVD The impact of combining SGLT-2 inhibitors and GLP-1 receptor agonists on cardiorenal outcomes has been evaluated in subgroup meta-analyses of CVOTs involving populations with type 2 diabetes and either established atherosclerotic CVD or multiple cardiovascular risk factors only

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However, the large size and complex structure of these macromolecules preclude their oral administration, greatly limiting their applications in patient care

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