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Potency loss can occur without visible signs

doi: 10.2174/1568010054526386 27 DilekFOzcekerDOzkayaEGulerEMYaziciMTamayZet al

Furthermore, risk of deficiencies of key nutrients that are essential cofactors, such as folate and B12, for methylation and conversion of homocysteine may increase in prevalence postmenopausally, in response to disruptions to oestrogen levels (Vasquez-Lorenete et al., 2022)

In some embodiments, formulations or compositions described herein provide a constant, sustained, extended, delayed or pulsatile rate of release of an active agent into the inner ear environment and thus avoid any variability in drug exposure in treatment of otic disorders