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Suliman IA, Lindgren JU, Elhassan AM, Diab KM, Adem A (2001) Effects of short- and long-term rat hind limb immobilization on spinal cord insulin-like growth factor-I and its receptor

The inner layer is loaded with bovine serum albumin-manganese dioxide nanoparticles (BM NPs), which continuously catalyze endogenous H 2 O 2 to generate O 2 , thereby alleviating hypoxia and augmenting photodynamic therapy

This approach reduces GI side effects further and is useful for patients with a history of GLP-1 intolerance

They now prioritize these agents for patients with: Type 2 diabetes and obesity Metabolic dysfunctionassociated steatotic liver disease (MASLD) Biopsy-proven or high-risk metabolic dysfunctionassociated steatohepatitis (MASH) Cardiovascular disease or heart failure risk Advanced chronic kidney disease This reflects a broader context view of diabetes as a multisystem condition