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An experimental model study demonstrated that spironolactone prevented the STZ-induced increase in the renal aldosterone synthase CYP11B2 mRNA content and did not influence glycemic level or BP in STZ-induced diabetic rats

However, the decreased HDL cholesterol and apoA1 concentrations induced by modified fasting are contradictory to that reported in previous studies [38, 40] which showed that these parameters increased during the zero-calorie fasting period

These drugs were originally developed for the management of Type 2 diabetes and work by suppressing appetite and so result in significant fat loss