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A number of small datasets have suggested a potential role for skewed X chromosome activation (XCI), away from the expected 50:50 parent of origin ratio, as an explanation for the strong female preponderance seen in the common autoimmune thyroid diseases (AITD), Graves disease (GD) and Hashimotos thyroiditis (HT)

Not all polypeptides are complete proteins, though

PIH, sun spots, dullness, and uneven skin tone occur due to environmental, hormonal, and lifestyle factors

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