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We also evaluated the ability of conditioned media (CM) from pre-treated PCa and BPH cells with ALCAR (1 or 10 mM), to interfere with the expression of CXCR4 (receptor for CXCL12), CXCR1, CXCR2 (receptors for CXCL8) and CCR2 (receptor for CCL2) on human umbilical vein endothelial cells (HUVEC

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These reports likely reflect reduced oxidative burden on mitochondrial function rather than direct stimulant activity

Apparently the bioavailability of caffeine obtained from coffee enemas is about 3.5 times less than those obtained drinking coffee orally