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Clinical data shows reductions in VAT beginning within 1 to 2 weeks, with substantial changes evident by 8 to 12 weeks of daily 2mg subcutaneous injections

Hanaoka, K., Sasakura, K., Suwanai, Y., Toma-Fukai, S., Shimamoto, K., Takano, Y

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However, participants with normal renal function had a slightly lower total exposure and rate of absorption than participants with renal impairment, but without a trend across the different renal impairment groups