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The randomised, double-blind, placebo-controlled trial enrolled adults with type 2 diabetes managed with diet and exercise alone or with stable oral antidiabetic therapy (excluding sulphonylureas and insulin in most arms)

The two most notable ones being: Preventing enzymatic cleavage replacing Ala2 with -aminoisobutyric acid (Aib) to remove the DPP-4 cleavage site and avoid degradation

For example, a handful of cases were seen with exenatide and liraglutide, while none were reported for albiglutide or taspoglutide at the time

Finally, in the MASLD clinical trial, liver fat reduction was closely related to improvements in cardiometabolic biomarkers, including body weight, insulin sensitivity, and triglyceride levels [58]