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The Endocrine Society's 2023 guideline on pharmacological management of obesity similarly limits GLP-1 RA recommendations to patients aged 12 and older, consistent with the Wegovy label (Endocrine Society Guideline) [8]

Retrieved from van Baak, M

Conversely, those with lower GLP1R or GIPR sensitivity may benefit from multimodal metabolic support, though berberine's AMPK mechanism differs from GLP-1/GIP signaling and should be interpreted with a qualified healthcare provider rather than as a guaranteed compensatory strategy

Gorostiaga, E