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This mutation was mainly observed in GBM, present in 3 GBM cases out of 8 patient samples with this mutation (cBioportal, COSMIC study - 329 COSU329 Glioblastoma Multiforme, TCGA), and was also observed in lung squamous cell carcinoma, clear cell renal cell carcinoma, colon adenocarcinoma, liver neoplasm and prostate carcinoma (Table S4)

The peptide upregulates expression of epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor among others

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There is no clear evidence that SCFAs can affect esophageal barrier function, but production of SCFAs in the colon is completely and rapidly absorbed by colonic cells and circulates systemically through the portal vein (95)