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D51.2 Transcobalamin II Deficiency Use for congenital transcobalamin II deficiency, a rare inherited disorder diagnosed in infancy

With regard to adhesion, resting, unstimulated primary T cells reportedly do not show significant binding to integrin ligands whereas certain Jurkat cell lines already show a high ligand-binding state, at least for the integrin ligand VCAM-1 54

90,91 However, gene editing approaches remain effective in treating inherent mtDNA mutations, while the ROS-induced sporadic and clonally expanding mtDNA mutations observed in -thalassemia and related hemoglobinopathies present challenges for current gene editing therapeutic strategies