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It typically starts with a low dose, which is adjusted based on how well the individual responds to and tolerates the medication

Plant Cell Environ 40:462472 Flores T et al (2008) Arginase-negative mutants of Arabidopsis exhibit increased nitric oxide signaling in root development

One year after the start of the treatment, researchers found that the average weight reduction was 3.6% among the participants who discontinued their treatment early, compared to 6.8% for those who discontinued their treatment late