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In an accelerated aging rat model, vitamin E supplementation reduced the number of nerve cells lost due to aging (La Fata et al., 2017), and improved memory and cognitive decline due to the loss of prefrontal cortical cells (Rafati et al., 2017)
Given the safety, relative low cost, and significant affect cobalamin deficiency can have on quality of life, we recommend B12 supplementation for all emaciated patients, regardless of whether access to serum cobalamin testing is available
They physically disrupt the electron transport chain, the series of protein complexes inside the mitochondria that generate ATP, leading to a catastrophic drop in cellular energy production
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