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However, the parenteral use of vitamin B12 has proven itself not only in pernicious anemia, the classic B12 deficiency disease, but also in polyneuropathies and mental disorders

This action suppresses hepatic glucose production and influences insulin sensitivity through activation of the PI3K-Akt-FoxO1 signaling cascade [17]

Oncogene 21 : 82408250 Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

It is characterized by chronic anovulation, hyperandrogenism, insulin resistance, and ovarian morphological changes (Rosenfield and Ehrmann, 2016)