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Genetic Predispositions in Detoxification and Glutathione Metabolism Variations in genes encoding glutathione S-transferases (GSTs), glutathione peroxidases (GPXs), and other antioxidant enzymes influence individual glutathione demand and responsiveness

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Certain circumstances may increase the body's demand for taurine, such as intense exercise and stress, and taurine synthesis also declines during the natural aging process

GSH depletion triggers cell cycle arrest in G1/S checkpoint and induces SIPS SIPS is well-characterized in cells treated with exogenous oxidants such as tBH and H 2 O 2 10,11