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As estrogen fluctuates in perimenopause and declines in menopause, several things happen simultaneously: Insulin resistance increases Visceral fat storage becomes easier Muscle mass gradually declines Resting metabolic rate slows Sleep becomes more disrupted Cortisol becomes more reactive Insulin resistance alone can change everything

But they are also precisely why a thorough understanding of GHK-Cu contraindications is non-negotiable

Local administration is commonly used because its effects appear strongest close to the target tissue