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In order to improve outcomes, biphasic scaffolds can be created with a softer upper layer containing chondrogenic factors (e.g., TGF-, chondroitin sulfate) and a stiffer lower layer, often loaded with calcium phosphate, hydroxyapatite, or bone morphogenetic protein (BMP), to provide structural support of the above cartilage layer and to promote osteogenic tissue formation and boney integration

It is how to do so most effectively, for whom, and when

MC1R in peripheral melanocytes driving melanogenesis, and central MC3R/MC4R in hypothalamic and limbic circuits driving sexual behaviour

These projections vary in base width from 50 to 250 m, heights between 25 and 2000 m, and diameters of tip from 1 to 25 m [238, 266]