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Fluoxetine is the only antidepressant with FDA approval for bulimia treatment, and it is prescribed at higher doses for this indication than for depression

Major barriers to the clinical use of gene therapy, however, include transfection efficiency, the creation of long-term effects, the difficulty of controlling cell proliferation, ectopic transfection, disease transmission, patient-specific dose responses, immune reactions against viral proteins, possible side effects, and ethical issues [87, 88]

Therefore, we assumed that ACTL6A might work cooperatively with NRF2 to regulate GCLC expression

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