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Oral methimazole appears more effective given twice daily rather than once daily 8 , the recommended regimen, whereas carbimazole can be effectively given once daily, with similar efficacy 9

While some individuals may notice subtle improvements in appetite, sleep, or energy shortly after starting treatment, most benefits develop gradually over time as the body responds to the peptides signaling effects

Adequate Caloric Intake Some patients on GLP-1s eat too little, leading to reduced sex hormones and fatigue

The bottom line: GLP-1 medications are a powerful tool, and the muscle loss concern while valid is manageable with the right approach