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27 As in the case of tirzepatide, combining GLP-1 RAs with other enteropancreatic hormones holds promise for larger body weight reductions compared with GLP-1 RAs alone

The medical community continues to monitor and study the long-term effects of semaglutide and other GLP-1 receptor agonists

On the other hand, while metformin is renowned for its safety profile and affordability, it often requires a cocktail of medications for optimal efficacy

A series of studies reported that GLP-1 stimulation had modulated central nervous system response to visual and gustatory food cues as assessed by functional MRI [41,42,43,44]