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Cagrilintide + Tirzepatide Storage & Handling Storage Reference (Both Compounds) State Lyophilized (long-term) Tirzepatide -4 F (-20 C), 12+ months Cagrilintide -4 F (-20 C), 12+ months State Lyophilized (short-term) Tirzepatide 35.6-46.4 F (2-8 C), several months Cagrilintide 35.6-46.4 F (2-8 C), several months State Reconstituted (liquid) Tirzepatide 35.6-46.4 F (2-8 C), 28-30 days Cagrilintide 35.6-46.4 F (2-8 C), 28-30 days State Color when reconstituted Tirzepatide Clear, colorless Cagrilintide Clear, colorless State Shake

It represents the zone where peptide bond stability remains high while ice crystal formation (which occurs below 0C) is prevented

In disparity, FGF19 remains unchanged, indicating its limited role in early human liver regeneration (210, 211)