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4,6 The most clinically significant elements of mucosal involvement are the sequelae of mucosal ulceration that result in scarring and stricture, which affect several organ systemsnamely, the cornea, urethra, esophagus, and pulmonary tract
These occur most frequently during the initial titration phase, as dosage is increased from a starting level toward a therapeutic target
Their job is to signal and guide other cells, tissues, and organs to respond to the hostile invaders