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DHA@MIL-101 NRs self-disassembled in the acid microenvironment to dissociate Fe 3+ , achieving GSH consumption-mediated redox reaction and Fe 2+ -mediated Fenton reaction (Figure 5D)

10.1210/jc.2016-2775 231

f , Control or INTS12 KO cells were either untreated or treated with UV (20 J/m2) followed by CHX (100 g/mL) treatment

Of note, whilst many studies have demonstrated the importance of ROS and macrophage function in other pathologies and physiological contexts, few have specifically investigated this link within wound healing pathophysiology 89