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The picture is consistent: the adverse events are overwhelmingly gastrointestinal, they track with dose, and they cluster during escalation

Unfortunately, with the possible exception of LPS and I-FABP, validation of these assays against standard permeability measurements and proper clinical validation studies in large groups of patients are missing and can therefore not be recommended to replace the direct permeability tests described above

Choosing the right diluent is therefore not a side detail it is part of the experimental design

With a few exceptions, the answers given are formulaic, show a lack of knowledge, understanding, empathy or care about the topic discussed