Common side effects across all semaglutide products include: Nausea Stomach pain, heartburn, diarrhea, constipation Vomiting Bloating Loss of appetite Low blood sugar Fatigue Injection site reactions (Wegovy and Ozempic) Headache Cold or flu-like symptoms Dizziness Serious side effects, though rare, may include: Allergic reactions (hives, facial/throat swelling, shortness of breath) Thyroid tumors (MTC or MEN 2): lump in neck, hoarseness, difficulty breathing or swallowing Pancreatitis: severe upper abdominal pain radiating to the back, increased heart rate, nausea Diabetic retinopathy complications: vision changes Severe hypoglycemia: sweating, blurred vision, dizziness, confusion, rapid heartbeat Kidney problems: decreased urination, thirst, dry skin Gallbladder issues: fever, claycolored stools, upper abdominal pain These are not all possible side effects
GHK-Cu has the strongest evidence base of the three, but that evidence is overwhelmingly topical
In addition, GLP-1RAs, reduce pancreatic islet -cell apoptosis, stimulate the proliferation and differentiation of -cells, and decrease body weight by suppressing food intake in patients with T2DM [8, 41,42,43]
Cagrilintide speaks to a completely different setamylin and calcitonin receptors